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Comprehensive characterization of nanomaterials for medical applications is achallenging and complex task due to the multitude of parameters which need tobe taken into consideration in a broad range of conditions. Routine methodssuch as dynamic light scattering or nanoparticle tracking analysis provide someinsight into the physicochemical properties of particle dispersions. Fornanomedicine applications the information they supply can be of limited use.For this reason, there is a need for new methodologies and instruments that canprovide additional data on nanoparticle properties such as their interactionswith surfaces. Nanophotonic force microscopy has been shown as a viable methodfor measuring the force between surfaces and individual particles in thenano-size range. Here we outline a further application of this technique tomeasure the size of single particles and based on these measurement build thedistribution of a sample. We demonstrate its efficacy by comparing the sizedistribution obtained with nanophotonic force microscopy to establishedinstruments, such as dynamic light scattering and differential centrifugalsedimentation. Our results were in good agreement to those observed with allother instruments. Furthermore, we demonstrate that the methodology developedin this work can be used to study complex particle mixtures and the surfacealteration of materials. For all cases studied, we were able to obtain both thesize and the interaction potential of the particles with a surface in a singlemeasurement.

Using single nanoparticle tracking obtained by nanophotonic force  microscopy to simultaneously characterize nanoparticle size distribution and  nanoparticle-surface interactions