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The resonance energy transfer (RET) from tryptophan present in bovine serumalbumin (BSA) to two dimensional (2D) nanomaterials has been reported. In thesebio-nano systems, BSA molecules act as efficient donors while 2D van der Waalsnanosheets of graphene, molybdenum disulfide (Mo$S_2$) and tungsten disulfide(W$S_2$) act as acceptors. The fluorescence emission from tryptophan arises at350 nm, in presence of 2D nanosheets, the fluorescence intensity of BSAdecreases. The time resolved fluorescence study shows that there is decrease inthe fluorescence lifetime of BSA molecules in presence of 2D nanosheets. Thedecrease in fluorescence lifetime of BSA confirms the energy transferphenomenon in bio-nano interactions. This study is important for finding thebio-compatibility of 2D nanomaterials in biological applications.

Investigating resonance energy transfer from protein molecules to van der Waals nanosheets