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Anesthetic agents are neurotropic drugs capable of inducing significantalterations in the thalamocortical system, promoting a profound decrease inawareness and level of consciousness. There is experimental evidence thatgeneral anesthesia affects large-scale functional networks, leading toalterations in the brain's state. However, the specific impact on the networkstructure assumed by functional connectivity locally in different corticalregions has not yet been reported. Within this context, the present study hassought to characterize the functional brain networks relative to the frontal,parietal, temporal, and occipital lobes. In this study, electrophysiologicalneural activity was recorded using a dense ECoG-electrode array placed directlyon the cortical surface of an old-world monkey of the species Macaca fuscata.Networks were estimated serially over time every five seconds, while the animalmodel was under controlled experimental conditions of a Ketamine-Medetomidineanesthetic induction. In each of the four cortical brain lobes, noticeablealterations in distinct properties of the networks evidenced a transition inthe network's architecture, which occurred within approximately one and a halfminutes after administering the anesthetics. The characterization of functionalbrain networks performed in this study provides relevant experimental evidencethat expands our understanding of the neural correlates of consciousness interms of the structure and properties of the functional brain networks.

Structure and Dynamics of Brain Lobe's Functional Networks at the Onset of Anesthesia-Induced Loss of Consciousness