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The epidemiology of lumbar degenerative spondylolisthesis (DS) remainscontroversial. We performed a systemic review with the aim to have a betterunderstanding of DS's prevalence in general population. The results showed theprevalence of DS is very gender specific and age specific. Both women and menhave few DS before 50 years old, after 50 years old both women and men start todevelop DS, with women having a faster developing rate than men. For elderlyChinese (>=65 yrs, mean age: 72.5 yrs), large population based studies(MsOS(Hong Kong) and MrOS (Hong Kong), females n=2000 and males n=2000) showedDS prevalence was for 25.0% for women and 19.1% for men, and the prevalence F:M(women:men) ratio was 1.3:1. The published data (MsOS(USA) and MrOS(USA)studies) seem to show elderly Caucasian American has a higher DS prevalence,being approximately 60-70% higher than elderly Chinese; however the prevalenceF:M ratio was similar to elderly Chinese population. Patient data showed femalepatients more often received treatment than men; and preliminary data show theratio of numbers of female patients received treatment compared with men didnot differ between Northeast Asians (Chinese, Japanese, and Korean) andEuropean and American Caucasians, being around 2:1 in elderly population. Theexisting data also suggest that menopause may be a contributing factor for theaccelerated DS development in post-menopausal

Lumbar degenerative spondylolisthesis epidemiology: a systemic review with a focus on gender-specific and age-specific prevalence