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Realistic simulations of experiments at large scale photon facilities, suchas optical laser laboratories, synchrotrons, and free electron lasers, are ofvital importance for the successful preparation, execution, and analysis ofthese experiments investigating ever more complex physical systems, e.g.biomolecules, complex materials, and ultra-short lived states of highly excitedmatter. Traditional photon science modelling takes into account only isolatedaspects of an experiment, such as the beam propagation, the photon-matterinteraction, or the scattering process, making idealized assumptions about theremaining parts, e.g.\ the source spectrum, temporal structure and coherenceproperties of the photon beam, or the detector response. In SIMEX, we haveimplemented a platform for complete start-to-end simulations, following theradiation from the source, through the beam transport optics to the sample ortarget under investigation, its interaction with and scattering from thesample, and its registration in a photon detector, including a realistic modelof the detector response to the radiation. Data analysis tools can be hooked upto the modelling pipeline easily. This allows researchers and facilityoperators to simulate their experiments and instruments in real life scenarios,identify promising and unattainable regions of the parameter space andultimately make better use of valuable beamtime.  This work is licensed under the Creative Commons Attribution 3.0 UnportedLicense: http://creativecommons.org/licenses/by/3.0/.

SIMEX: Simulation of Experiments at Advanced Light Sources