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The spatial arrangement of galaxies (of satellites on a scale of 100kpc) aswell as their three-dimensional distribution in galaxy groups such as the LocalGroup (on a scale of 1Mpc), the distribution of galaxies in the nearby volumeof galaxies (on a scale of 8Mpc) and in the nearby Universe (on a scale of1Gpc) is considered. There is further evidence that the CMB showsirregularities and for anisotropic cosmic expansion. The overall impression oneobtains, given the best data we have, is matter to be arranged as not expectedin the dark-matter based standard model of cosmology (SMoC). There appears tobe too much structure, regularity and organisation. Dynamical friction on thedark matter halos is a strong direct test for the presence of dark matterparticles, but this process does not appear to be operative in the realUniverse. This evidence suggests strongly that dynamically relevant dark matterdoes not exist and therefore cosmology remains largely not understoodtheoretically. More-accepted awareness of this case would by itself constitutea major advance in research providing fabulous opportunities for bright minds,and the observational data strongly suggest that gravitation must beeffectively Milgromian, corresponding to a generalized Poisson equation in theclassical limit. Thus, physical cosmology offers a significant historicallyrelevant opportunity for ground-breaking work, at least for those daring to doso.

The observed spatial distribution of matter on scales ranging from  100kpc to 1Gpc is inconsistent with the standard dark-matter-based  cosmological models