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Thermodynamic scaling explains the dramatic successes of CTP fused humangrowth proteins as regards lifetime in vivo and enhanced functionality comparedto their wild-type analogues, like Biogen. The theory is semi-quantitative andcontains no adjustable parameters. It shows how hydrophilic terminal spheresorient fused proteins in the neighborhood of a membrane surface, extendinglifetimes and improving functionality.

Mechanism for long-acting chimeras based on fusion with the carboxyl-terminal peptide (CTP) of human chorionic gonadotropin beta-subunit 3