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How cells move through the three-dimensional extracellular matrix (ECM) is ofincreasing interest in attempts to understand important biological processessuch as cancer metastasis. Just as in motion on flat surfaces, it is expectedthat experimental measurements of cell-generated forces will provide valuableinformation for uncovering the mechanisms of cell migration. However, therecovery of forces in fibrous biopolymer networks may suffer from large errors.Here, within the framework of lattice-based models, we explore possible issuesin force recovery by solving the inverse problem: how can one determine theforces cells exert to their surroundings from the deformation of the ECM? Ourresults indicate that irregular cell traction patterns, the uncertainty oflocal fiber stiffness, the non-affine nature of ECM deformations and inadequateknowledge of network topology will all prevent the precise force determination.At the end, we discuss possible ways of overcoming these difficulties.

Hindrances to precise recovery of cellular forces in fibrous biopolymer networks