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We investigate a model of an asymmetric bilayer consisting of sphigomyelin,phosphatidylcholine, and cholesterol in the outer leaflet, andphosphatidyl\-ethanolamine, (PE), phosphatidylserine, and cholesterol in theinner leaflet. Composition fluctuations are coupled to membrane fluctuationsvia the bending energy which depends upon the local spontaneous curvaturedominated by the PE in the inner leaflet. This brings about a microemulsion inthat leaflet with a characteristic wavelength of 37 nm as shown by the PE-PEstructure function. Thus the inner leaflet will respond to an externalperturbation most strongly at this length. However the correlation length isapproximately 1 nm so that composition variations are not seen in the innerleaflet itself. Depending upon the strength of the coupling between leaflets,the outer leaflet is either a normal fluid or is also a microemulsion. In thismodel then, the lipids of the plasma membrane would not evince inhomogeneities,but would be primed to create them from the inner leaflet in response tonon-lipid perturbations.

Model plasma membrane indicates the inner leaflet is poised to initiate compositional heterogeneities