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A previous report claimed no evidence of transgenerational epigeneticinheritance in a mouse model of in utero environmental exposure, based on theobservation that gene expression changes observed in the germ cells of G1 andG2 male fetus were not in the same direction. A subsequent data reanalysishowever showed a statistically significant overlap between G1 and G2 genesirrespective of direction, leading to the suggestion that, as phenotypicvariability in epigenetic transmission has been observed in several otherexamples also, the above report provided evidence in favor of, not against,transgenerational inheritance. This criticism has recently been questioned.Here, it is shown that the questions raised are based not only on incorrectstatistical calculations but also on wrong premise that gene expression changesdo not constitute a phenotype.

Reanalyzing variable directionality of gene expression in transgenerational epigenetic inheritance