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We show experimentally that a cheap glass microcapillary can accumulate{\lambda}-phage DNA at its tip and deliver the DNA into the capillary using acombination of electro-osmotic flow, pressure-driven flow, and electrophoresis.We develop an efficient simulation model for this phenomenon based on theelectrokinetic equations and the finite-element method. Using our model, weexplore the large parameter space of the trapping mechanism by varying the saltconcentration, the capillary surface charge, the applied voltage, the pressuredifference, and the mobility of the analyte molecules. Our simulation resultsshow that this system can be tuned to capture a wide range of analytemolecules, such as DNA or proteins, based on their electrophoretic mobility.Our method for separation and pre-concentration of analytes has implicationsfor the development of low-cost lab-on-a-chip devices.

Selective Trapping of DNA using Glass Microcapillaries