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Background: A deterministic model is developed for the spatial spread of anepidemic disease in a geographical setting. The disease is borne by vectors tosusceptible hosts through criss-cross dynamics. The model is focused on anepidemic outbreak that initiates from a small number of cases in a smallsub-region of the geographical setting. Methods: Partial differential equationsare formulated to describe the interaction of the model compartments. Results:The partial differential equations of the model are analyzed and proven to bewell-posed. The epidemic outcomes of the model are correlated to the spatiallydependent parameters and initial conditions of the model. Conclusions: Aversion of the model is applied to the 2015-2016 Zika outbreak in the Rio deJaneiro Municipality in Brazil.

An Outbreak Vector-host Epidemic Model with Spatial Structure: The 2015 Zika Outbreak in Rio de Janeiro