English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Tissue remodelling in diverse developmental contexts require cell shapechanges that have been associated with pulsation and flow of the actomyosincytoskeleton. Here we describe the dynamics of the actomyosin cytoskeleton as aconfined active elastomer embedded in the cytosol and subject to turnover ofits components. Under affine deformations (homogeneous deformation over aspatially coarse-grained scale), the active elastomer exhibits spontaneousoscillations, propagating waves, contractile collapse and spatiotemporal chaos.The collective nonlinear dynamics shows nucleation, growth and coalescence ofactomyosin-dense regions which, beyond a threshold, spontaneously move as aspatially localized traveling front towards one of the boundaries. However,large myosin-induced contractile stresses, can lead to nonaffine deformationsdue to actin turnover. This results in a transient actin network, thatnaturally accommodates intranetwork flows of the actomyosin dense regions as aconsequence of filament unbinding and rebinding. Our work suggests that thedriving force for the spontaneous movement comes from the actomyosin-denseregion itself and not the cell boundary. We verify the many predictions of ourstudy in Drosophila embryonic epithelial cells undergoing neighbour exchangeduring a collective process of tissue extension called germband extension.

Actomyosin pulsation and symmetry breaking flows in a confined active elastomer subject to affine and nonaffine deformations