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Sickle cell disease (SCD) is common across Sub-Saharan Africa. However, theinvestigation of SCD in this area has been significantly limited mainly due tothe lack of research facilities and skilled personnel. Here, we present opticalmeasurements of individual red blood cells (RBCs) from healthy individuals andindividuals with SCD and sickle cell trait in Tanzania using the quantitativephase imaging technique. By employing a quantitative phase imaging unit (QPIU),an existing microscope in a clinic is transformed into a powerful quantitativephase microscope providing measurements on the morphological, biochemical, andbiomechanical properties of individual cells. The present approach will open upnew opportunities for cost-effective investigation and diagnosis of severaldiseases in low resource environments.

Optical characterization of red blood cells from individuals with sickle cell trait and disease in Tanzania using quantitative phase imaging