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Structural plasticity in the brain (i.e. rewiring the connectome) may beviewed as mechanisms for dynamic reconfiguration of neural circuits. Firstorder computations in the brain are done by static neural circuits, whereashigher order computations are done by dynamic reconfigurations of the links(synapses) between the neural circuits. Static neural circuits correspond tofirst order computable functions. Synapse creation (activation) between themcorrespond to the mathematical notion of function composition. Functionals arehigher order functions that take functions as their arguments. The constructionof functionals is based on dynamic reconfigurations of function compositions.Perhaps the functionals correspond to rewiring mechanisms of the connectome.The architecture of human mind is different than the von Neumann computerarchitecture. Higher order computations in the human brain (based onfunctionals) may suggest a non-von Neumann computer architecture, a challengeposed by John Backus in 1977 \cite{Backus}. The presented work is a substantialextension and revision of the paper published in Proc. ICANN2016.

On higher order computations, rewiring the connectome, and non-von Neumann computer architecture