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Living systems, particularly multicellular systems, often seem hopelesslycomplex. But recent studies have suggested that beneath this complexity, theremay be unifying quantitative principles that we are only now starting tounravel. All cells interact with their environments and with other cells.Communication among cells is a primary means for cells to interact with eachother. The complexity of these multicellular systems, due to the large numbersof cells and the diversity of intracellular and intercellular interactions,makes understanding multicellular systems a daunting task. To overcome thischallenge, we will likely need judicious simplifications and conceptualframeworks that can reveal design principles that are shared among diversemulticellular systems. Here we review some recent progress towards developingsuch frameworks.

Progress towards quantitative design principles of multicellular systems