English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Network analysis is a powerful way of modeling chromatin interactions.Assortativity is a network property used in social sciences to identify factorsaffecting how people establish social ties. We propose a new approach, usingchromatin assortativity to integrate the epigenomic landscape of a specificcell type with its chromatin interaction network and thus investigate whichproteins or chromatin marks mediate genomic contacts. We use high-resolutionPromoter Capture Hi-C and Hi-Cap data as well as ChIA-PET data from mouseembryonic stem cells to investigate promoter-centered chromatin interactionnetworks and calculate the presence of specific epigenomic features in thechromatin fragments constituting the nodes of the network. We estimate theassociation of these features to the topology of four chromatin interactionnetworks and identify features localized in connected areas of the network.Polycomb Group proteins and associated histone marks are the features with thehighest chromatin assortativity in promoter-centred networks. We then ask whichfeatures distinguish contacts amongst promoters from contacts between promotersand other genomic elements. We observe higher chromatin assortativity of theactively elongating form of RNA Polymerase 2 (RNAPII) compared to inactiveforms only in interactions between promoters and other elements. Contacts amongpromoters, and between promoters and other elements have differentcharacteristic epigenomic features. We identify a possible role for theelongating form of RNAPII in mediating interactions among promoters, enhancersand transcribed gene bodies. Our approach facilitates the study of multiplegenome-wide epigenomic profiles, considering network topology and allowing thecomparison of chromatin interaction networks.

Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity