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Knowledge of thermal history in biological tissues during laser basedhyperthermia is essential to achieve necrosis of tumour orcarcinoma cells. Asemi analytical model to predict sub surface thermal history in translucent,soft, bio tissue mimics has been proposed. The model can accurately predict thespatio temporal temperature variations along depth and the anomalous thermalbehaviour in such media, viz. occurrence of sub surface temperature peaks.Based on opto thermal properties, the augmented temperature and shift of thepeak positions in case of gold nanostructure mediated tissue phantomhyperthermia can be predicted. Employing inverse approach, the absorbancecoefficient of nano graphene infused tissue mimics is determined from the peaktemperature and found to provide appreciably accurate predictions along depth.Furthermore, a simplistic, dimensionally consistent correlation totheoretically determine the position of the peak in such media is proposed andfound to be consistent with experiments and computations. The model showspromise in predicting thermal history in optically active soft matter anddeduction of therapeutic hyperthermia parameters, thereby providing a prioriestimates for clinical trials.

Analytical prediction of sub surface thermal history in translucent tissue phantoms during plasmonic photo thermotherapy