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It is well known that cyclins are a family of proteins that controlcell-cycle progression by activating cyclin-dependent kinase. Based on ourexperimental results, we propose here a novel hypothesis that certain amplifiedgenomic-DNA fragments (AGFs) may also be required for the cell cycleprogression of eukaryotic cells and thus can be named as cell-cycle-associatedAGFs (CAGFs). Like fluctuation in cyclin levels during cell cycle progression,these CAGFs are amplified and degraded at different points of the cell cycle.The functions of CAGFs are unknown, but we speculate that CAGFs might beinvolved in regulation of gene expression, genome protection, and formation ofcertain macromolecular complexes required for the dynamic genome architectureduring cell cycle progression. Our experimental results also show thatchloroquine induces the production of CAGFs in Plasmodium falciparum,suggesting that targeting cell cycle progression can be the primary mechanismof chloroquine's antimalarial, anticancer, and immunomodulatory actions.

Certain amplified genomic-DNA fragments (AGFs) may be involved in cell  cycle progression and chloroquine is found to induce the production of  cell-cycle-associated AGFs (CAGFs) in Plasmodium falciparum