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A sensation of fullness in the bladder is a regular experience, yet themechanisms that act to generate this sensation remain poorly understood. Thisis an important issue because of the clinical problems that can result whenthis system does not function properly. The aim of the study group activity wasto develop mathematical models that describe the mechanics of bladder filling,and how stretch modulates the firing rate of afferent nerves. Several modelswere developed, which were qualitatively consistent with experimental dataobtained from a mouse model.

Modelling afferent nerve responses to bladder filling