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Negative emotional responses to the daily life stresses have cumulativeeffects which, in turn, impose wide-ranging negative constraints on emotionalwell being and neurocognitive performance (Kalueff:2007cp, Charles:2013eq,Nadler:2010hk). Crucial cognitive functions such as memory and problem solving,as well more short term emotional responses (e.g., anticipation of- andresponse to- monetary rewards or losses) are influenced by mood. The negativeimpact of these behavioural responses is felt at the individual level, but italso imposes major economic burden on modern healthcare systems. Although muchresearch have been undertaken to understand the underlying mechanisms ofdepressed mood and design efficient treatment pathways, comparatively littlewas done to characterize mood modulations that remain within the boundaries ofa healthy mental functioning. In one placebo-controlled experiments, we applieddaily prefrontal transcranial Direct Current Stimulation (tDCS) at five pointsin time, and found reliable improvements on self-reported mood evaluation. Wereplicated this finding in an independent double-blinded placebo-controlledexperiment and showed that stimulation over a shorter period of time (3 days)is sufficient to create detectable mood improvements. Taken together, our datashow that repeated bilateral prefrontal tDCS can reduce psychological distressin nondepressed individuals.

Repeated transcranial direct current stimulation (tDCS) in nondepressed reduces levels of reported negative affects from daily stressors