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The investigation of the neuronal environment allows us to better understandthe activity of a cerebral region as a whole. The recent experimental evidencesof the presence of transporters for glutamate and GABA in both neuronal andastrocyte compartments raise the question of the functional importance of theastrocytes in the regulation of the neuronal activity. We propose a newcomputational model at the mesoscopic scale embedding the recent knowledge onthe physiology of neuron and astrocyte coupled activities. The neuralcompartment is a neural mass model with double excitatory feedback, and theglial compartment focus on the dynamics of glutamate and GABA concentrations.Using the proposed model, we first study the impact of a deficiency in thereuptake of GABA by astrocytes, which implies an increase in GABA concentrationin the extracellular space. A decrease in the frequency of neural activity isobserved and explained from the dynamics analysis. Second, we investigate theneuronal response to a deficiency in the reuptake of Glutamate by theastrocytes. In this case, we identify three behaviors : the neural activity mayeither be reduced, or enhanced or, alternatively, may experience a transient ofhigh activity before stabilizing around a new activity regime with a frequencyclose to the nominal one. After translating theoretically the neuronalexcitability modulation using the bifurcation structure of the neural massmodel, we state the conditions on the glial feedback parameters correspondingto each behavior.

A theoretical study of the role of astrocyte activity in neuronal hyperexcitability using a new neuro-glial mass model