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Effective and controlled drug delivery systems with on-demand releaseabilities and biocompatible properties receive enormous attention forbiomedical applications. Here, we describe a novel inorganic-organic hybridmaterial with a strikingly high organic content of almost 50 wt%. The colloidalperiodic mesoporous organosilica (PMO) nanoparticles synthesized in this workconsist entirely of curcumin and ethane derivatives serving as constituentsthat are crosslinked by siloxane bridges, without any added silica. Thesemesoporous curcumin nanoparticles (MCNs) exhibit very high surface areas (over1000 m2/g), narrow particle size distribution (around 200 nm) and a strikinglyhigh stability in simulated biological media. Additionally, the MCNs are usedas a cargo delivery system in live-cell experiments. A supported lipid bilayer(SLB) efficiently seals the pores and releases Rhodamin B as model cargo inHeLa cells. This novel nanocarrier concept provides a promising platform forthe development of controllable and highly biocompatible theranostic systems.

Lipid Bilayer-Coated Curcumin-based Mesoporous Organosilica Nanoparticles for Cellular Delivery