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Misrepair accumulation theory is a novel theory in interpreting agingphenomena. With a new concept of Misrepair, this theory reaches a unifiedunderstanding of aging: aging of an organism is a result of accumulation ofMisrepairs of its structure. Misrepair accumulation theory (MA theory) isdistinct and it can improve our understanding of life on several aspects. I. MAtheory is fundamentally different from other theories by: A. proposing ageneralized concept of Misrepair; B. pointing out the evolutionary advantage ofaging mechanism; and C. distinguishing between aging of a cell and aging of atissue. II. MA theory overcomes the limitations of traditional theories oninterpreting the phenomena of tissue fibrosis and cancer development. Tissuefibrosis, as a result of accumulation of Misrepairs with collagen fibers, is apowerful evidence for demonstrating the central role of Misrepairs in aging.Cancer development is a result of accumulation of DNA Misrepairs in somaticcells, which needs to proceed over many generations of cells in a regenerabletissue. III. MA theory improves also our understanding on longevity, prematureaging, adaptation, and species evolution. The potential of longevity of anorganism is hidden in the complexity of its structure. IV. MA theory suggeststhat for retarding aging, the most important is to reduce the opportunity ofdamage-exposure.

Misrepair accumulation theory: a theory for understanding aging, cancer development, longevity, and adaptation