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Optimal experimental design approaches are seldom used in pre-clinical drugdiscovery. Main reasons for this lack of use are that available software toolsrequire relatively high insight in optimal design theory, and that thedesign-execution cycle of in vivo experiments is short, making time-consumingoptimizations infeasible. We present the publicly available software PopED litein order to increase the use of optimal design in pre-clinical drug discovery.PopED lite is designed to be simple, fast and intuitive. Simple, to give manyusers access to basic optimal design calculations. Fast, to fit the shortdesign-execution cycle and allow interactive experimental design (test onedesign, discuss proposed design, test another design, etc). Intuitive, so thatthe input to and output from the software can easily be understood by userswithout knowledge of the theory of optimal design. In this way, PopED lite ishighly useful in practice and complements existing tools. Key functionality ofPopED lite is demonstrated by three case studies from real drug discoveryprojects.

PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies