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Hutchinson-Gilford Progeria syndrome, Werner syndrome, and Cockayne syndromeare three genetic disorders, in which the children have premature agingfeatures. To understand the phenomenon of premature aging, the similarity ofaging features in these syndromes to that in normal aging is investigated.Although these three syndromes have different genetic backgrounds, all thepatients have abnormal structures of tissues/organs like that in normal aging.Therefore, the abnormality in tissue structure is the common point in prematureaging and normal aging. This abnormality links also a defective development anda defective repair, the Misrepair. Defective development is a result ofMis-construction of the structure of tissues and organs as consequence ofgenetic mutations. Aging is a result of Mis-reconstructions, the Misrepairs,for maintaining the structure of tissues/organs. Construction-reconstruction ofthe structure of an organism is thus the coupling point of development andaging. Mis- construction and Mis-reconstruction (Misrepair) are the essentialprocesses for the development of aging-like feathers. In conclusion, prematureaging is a result of Mis- construction of tissues and organs during bodydevelopment as consequence of genetic disorders.

Premature aging as a consequence of Mis-construction of tissues and organs during body development