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Development of a tumor is known to be a result of accumulation of DNA changesin somatic cells. However, the processes of how DNA changes are produced andhow they accumulate in somatic cells are not clear. DNA changes include twotypes: point DNA mutations and chromosome changes. However, point DNA mutations(DNA mutations) are the main type of DNA changes that can remain and accumulatein cells. Severe DNA injuries are the causes for DNA mutations. However,Misrepair of DNA is an essential process for transforming a DNA injury into asurvivable and inheritable DNA mutation. In somatic cells, Misrepair of DNA isthe main source of DNA mutations. Since the surviving chance of a cell byMisrepair of DNA is low, accumulation of DNA mutations can take place onlypossibly in the cells that can proliferate. Tumors can only develop in thetissues that are regenerable. The accumulation of Misrepairs of DNA needs toproceed in many generations of cells, and cell transformation from a normalcell into a tumor cell is a slow and long process. However, once a cell istransformed especially when it is malignantly transformed, the deficiency ofDNA repair and the rapid cell proliferation will accelerate the accumulation ofDNA mutations. The process of accumulation of DNA mutations is actually theprocess of aging of a genome DNA. Repeated cell injuries and repeated cellregenerations are the two preconditions for tumor-development. For cancerprevention, a moderate and flexible living style is advised.

Cell transformation in tumor-development: a result of accumulation of Misrepairs of DNA through many generations of cells