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The AMS-02 collaboration has just released the cosmic antiproton to protonratio $\bar{p}/p$ with a high precision up to $\sim 450$ GeV. In this work, wecalculate the secondary antiprotons generated by cosmic ray interactions withthe interstellar medium taking into account the uncertainties from the cosmicray propagation. The $\bar{p}/p$ ratio predicted by these processes shows sometension with the AMS-02 data in some regions of propagation parameters, but theexcess is not significant. We then try to derive upper bounds on the darkmatter annihilation cross section from the $\bar{p}/p$ data or signal regionsfavored by the data. It is shown that the constraint derived by the AMS-02 datais similar to that from Fermi-LAT observations of dwarf galaxies. The signalregion for dark matter is usually required $m_\chi \sim O(10)$ TeV and$\left<\sigma v\right>\sim\mathcal{O}(10^{-23})~\cm^3~\sec^{-1}$.

Implications for dark matter annihilation from the AMS-02 $\bar{p}/p$ ratio