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In this paper, we consider the bacterial point-to-point communication problemwith one transmitter and one receiver by considering the ligand receptorbinding process. The most commonly investigated signalling model, referred toas the Level Scenario (LS), uses one type of a molecule with differentconcentration levels for signaling. An alternative approach is to employmultiple types of molecules with a single concentration level, referred to asthe Type Scenario (TS). We investigate the trade-offs between the two scenariosfor the ligand receptor from the capacity point of view. For this purpose, weevaluate the capacity using numerical algorithms. Moreover, we derive an upperbound on the capacity of the ligand receptor using a Binomial Channel (BIC)model using symmetrized Kullback-Leibler (KL) divergence. A lower bound is alsoderived when the environment noise is negligible. Finally, we analyse theeffect of blocking of a receptor by a molecule of a different type, byproposing a new Markov model in the multiple-type signalling.

On the Capacity of Level and Type Modulation in Molecular Communication with Ligand Receptors