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This manuscript has been written to address questions related to our recentpublication (Science 347:78-81, 2015). We appreciate the many reactions to thispaper that have been communicated to us, either privately or publicly. Thefollowing addresses several of the most important statistical and technicalissues related to our analysis and conclusions. Our responses to non-technicalquestions are available athttp://www.hopkinsmedicine.org/news/media/releases/bad_luck_of_random_mutations_plays_predominant_role_in_cancer_study_shows

Musings on the theory that variation in cancer risk among tissues can be explained by the number of divisions of normal stem cells