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The aim of this paper is to give an introductory review of the cryoelectronmicroscopy as a complex data source for the most of the system biologybranches, including the most perspective non-local approaches known as"localomics" and "dynamomics". A brief summary of various cryoelectronmi-croscopy methods and corresponding system biological ap-proaches is given inthe text. The above classification can be considered as a useful framework forthe primary comprehen-sions about cryoelectron microscopy aims and instrumentaltools. We do not discuss any of these concepts in details, but merely point outthat their methodological complexity follows only from the structure-functionalcomplexity of biological systems which are investigated in this manner. We alsopostu-late that one can employ some of the cryoelectron microscopic techniquesnot only for observation, but also for modification and structuralrefunctionalization of some biological and similar soft matter objects andmicroscopic samples. In other worlds, we start with the cryoelectron microscopyas a tool for the sys-tem biology and progress to its applying as an instrumentfor system biology and functional biomimetics; i.e. "system cryobi-ology" goesover into "synthetic cryobiology" or "cryogenic biomimetics". All theseconclusions can be deduced from the most recent works of the latest years,including just submitted foreign papers. This article provides an up-to-datedescription of the conceptual basis for the novel view on the computationalcryoelectron microscopy (in silico) approaches and the data mining principleswhich lie at the very foundation of modern structural analysis andreconstruction.

Cryoelectron Microscopy as a Functional Instrument for Systems Biology,  Structural Analysis & Experimental Manipulations with Living Cells. A  comprehensive review of the current works