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The purpose of this study was to enhance the existing time dependent fluxmodel for the transdermal iontophoretic transport of drugs. This studyevaluated the flux data as influenced by time and current density. In vitroiontophoresis performed on the piglet (Sus scrofa) necropsy-taken medial scaphapinneal skin that mounted in the U shaped sink chamber. Iontophoresis ofatenolol with a constant dose of 1000 ppm was implemented for 3 hours withacceptor phase sampling every 30 minutes. Data were analised based onexponential fitting of each current density value to produce a current densitydependent flux model. This model then combined with the time differential modelof flux to produce a flux model that takes account of both current density andtime.

In-vitro iontophoresis of pinneal Sus scrofa skin and its transport flux modelling as influenced by time and current density