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We report results of an experimental study, complemented by detailedstatistical analysis of the experimental data, on the development of a moreeffective control method of drug delivery using a pH sensitive acrylic polymer.New copolymers based on acrylic acid and fatty acid are constructed fromdodecyl castor oil and a tercopolymer based on methyl methacrylate, acrylicacid and acryl amide were prepared using this new approach. Water swellingcharacteristics of fatty acid, acrylic acid copolymer and tercopolymerrespectively in acid and alkali solutions have been studied by a step-changemethod. The antibiotic drug cephalosporin and paracetamol have also beenincorporated into the polymer blend through dissolution with the release of theantibiotic drug being evaluated in bacterial stain media and buffer solution.Our results show that the rate of release of paracetamol getss affected by thepH factor and also by the nature of polymer blend. Our experimental data havelater been statistically analyzed to quantify the precise nature of polymerdecay rates on the pH density of the relevant polymer solvents. The timeevolution of the polymer decay rates indicate a marked transition from a linearto a strictly non-linear regime depending on the whether the chosen sample is ageneral copolymer (linear) or a tercopolymer (non-linear). Non-linear dataextrapolation techniques have been used to make probabilistic predictions aboutthe variation in weight percentages of retained polymers at all future times,thereby quantifying the degree of efficacy of the new method of drug delivery.

New oil modified acrylic polymer for pH sensitive drug release: Experimental results and statistical analysis