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We present new empirical evidence, based on millions of interactions onTwitter, confirming that human contacts scale with population sizes. Weintegrate such observations into a reaction-diffusion metapopulation frameworkproviding an analytical expression for the global invasion threshold of acontagion process. Remarkably, the scaling of human contacts is found tofacilitate the spreading dynamics. Our results show that the scaling propertiesof human interactions can significantly affect dynamical processes mediated byhuman contacts such as the spread of diseases, and ideas.

The Scaling of Human Contacts in Reaction-Diffusion Processes on Heterogeneous Metapopulation Networks