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The surface of biomaterials used as implants are highly susceptible tobacterial colonization and subsequent infection. The amount of proteinadsorption on biomaterials, among other factors, can affect the nature andquality of biofilms formed on them. The variation in the adsorption time of theprotein on the biomaterial surface produces a phenotypic change in the bacteriaby alteration of the production of EPS (exoplysaccharide) matrix. Knowledge ofthe effects of protein adsorption on implant infection will be very useful inunderstanding the chemistry of the biomaterial surfaces, which can deter theformation of biofilms. It is observed that the adsorption of BSA on thebiomaterial surfaces increases with time and concentration, irrespective oftheir type and the nature of the EPS matrix of the bacterial biofilm isdependent on the amount of protein adsorbed on the biomaterial surface. Theadsorption of protein (BSA) on the biomaterials, polypropylene (PP) and highdensity polyethylene (HDPE) has been studied and the formation of the biofilmsof Pseudomonas aeruginosa on them has been examined.

Studies of protein adsorption on implant materials in relation to  biofilm formation I. Activity of Pseudomonas aeruginosa on Polypropylene and  High density Polyethylene in presence of serum albumin