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We propose a novel and easy-to-implement joint location-scale associationtesting procedure that can account for complex genetic architecture withoutexplicitly modeling interaction effects, and is suitable for large-scalewhole-genome scans and meta-analyses. We focus on Fisher's method and use it tocombine evidence from the standard location test and the more recent scaletest, and we describe its use for single-variant, gene-set and pathwayassociation analyses.

A novel joint location-scale testing framework for improved detection of variants with main or interaction effects