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The measurement of di-Higgs physics can provide crucial information onelectroweak phase transition in the early Universe and significant clues on newphysics coupling with the Higgs field directly. This measurement has beensuggested to be pursued mainly via the $pp \to hh$ production. In this letter,we propose a new strategy to do that, i.e., via the $pp \to t \bar t hh $production. Because of its positive correlation with the rescaled tri-Higgscoupling $\frac{\lambda}{\lambda_{\rm SM}}$ (in comparison to a negative onefor the $pp \to hh$ production) in the neighborhood of$\frac{\lambda}{\lambda_{\rm SM}} \sim 1$, the $pp \to t\bar t hh$ productioncomplements the $pp \to hh$ one in measuring di-Higgs physics, particularly for$\frac{\lambda}{\lambda_{\rm SM}}>1$, at both the High Luminosity LHC (HL-LHC)and a next-generation $pp$-collider. As an illustration, we work on the process$pp\to t\bar thh \to t\bar t b\bar b b\bar b$. We show that a statisticalsignificance of $> 2.0 \sigma$ at the HL-LHC, comparable to that of the $pp \tohh \to b\bar b \gamma\gamma$ channel, and a statistical significance of $\sim 5\sigma$ at a 100 TeV $pp$-collider, with 3000 fb$^{-1}$ of data, are achievablein searching for the di-Higgs production with $\frac{\lambda}{\lambda_{\rm SM}}= 1$.

Measuring Di-Higgs Physics via the $t \bar t hh \to t \bar t b \bar bb\bar b$ Channel