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Defaults in vascular (VN) and neuronal networks of spinal cord areresponsible for serious neurodegenerative pathologies. Because of inadequateinvestigation tools, the lacking knowledge of the complete fine structure of VNand neuronal systems is a crucial problem. Conventional 2D imaging yieldsincomplete spatial coverage leading to possible data misinterpretation, whereasstandard 3D computed tomography imaging achieves insufficient resolution andcontrast. We show that X-ray high-resolution phase-contrast tomography allowsthe simultaneous visualization of three-dimensional VN and neuronal systems ofmouse spinal cord at scales spanning from millimeters to hundreds ofnanometers, with neither contrast agent nor a destructive sample-preparation.We image both the 3D distribution of micro-capillary network and themicrometric nerve fibers, axon-bundles and neuron soma. Our approach is acrucial tool for pre-clinical investigation of neurodegenerative pathologiesand spinal-cord-injuries. In particular, it should be an optimal tool toresolve the entangled relationship between VN and neuronal system.

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord