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How to induce differentiated cells into pluripotent cells has elicitedresearchers' interests for a long time since pluripotent stem cells are able tooffer remarkable potential in numerous subfields of biological research.However, the nature of cell reprogramming, especially the mechanisms stillremain elusive for the sake of most protocols of inducing pluripotent stemcells were discovered by screening but not from the knowledge of generegulation networks. Generally there are two hypotheses to elucidate themechanism termed as elite model and stochastic model which regard reprogrammingprocess a deterministic process or a stochastic process, respectively. However,the difference between these two models cannot yet be discriminatedexperimentally. Here we used a general mathematical model to elucidate thenature of cell reprogramming which can fit both hypotheses. We investigatedthis process from a novel perspective, the timing. We calculated the time ofreprogramming in a general way and find that noise would play a significantrole if the stochastic hypothesis holds. Thus the two hypotheses may bediscriminated experimentally by counting the time of reprogramming in differentmagnitudes of noise. Because our approach is general, our results shouldfacilitate broad studies of rational design of cell reprogramming protocols.

Theoretical modelling discriminates the stochastic and deterministic hypothesis of cell reprogramming