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Parkinson disease is a very common neurodegenerative disorder. Patientsusually undergo destruction of substantia nigra to develop typical symptomssuch as resting tremor, hypokinesia, and rigidity. However, the exact mechanismof Parkinson disease is still unknown, so it is called idiopathic Parkinsonism.According to my microarray analysis of peripheral blood leukocytes andsubstantia nigra brain tissue, I propose that Parkinson disease is actually aTH17 dominant autoimmune disease. Based on the microarray data in substantianigra, HSP40, HSP70, HSP90, HSP27, HSP105, TLR5, TLR7, CEBPB, CEBPG, FOS, andcaspase1 are significantly up-regulated. In peripheral leukocytes, NFKB1A,CEBPD, FOS, retinoic receptor alpha, suppressor of IKK epsilon, S100A11, G-CSF,MMP9, IL-1 receptor, IL-8 receptor, TNF receptor, caspase8, c1q receptor,cathepsin Z, HLA-G, complement receptor1, and complement 5a receptor. Generalimmune related genes are also up-regulated including ILF2, CD22, CD3E, BLNK,ILF3, TCR alpha, TCR zeta, TCR delta, LAT, ITK, Ly9, and BANK1. The autoantigenis mainly alpha-synuclein. After knowing the exact disease pathophysiology, wecan develop better drugs to prevent or control the detrimental disorder.

Parkinson disease is a TH17 dominant autoimmune disorder against accumulated alpha-synuclein