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Communication via diffusion (CvD) is an effective and energy efficient methodfor transmitting information in nanonetworks. In this work, we focus on adiffusion-based communication system where the reception process is anabsorption via receptors. Whenever a molecule hits to the receiver it isremoved from the environment. This kind of reception process is called firstpassage process and it is more complicated compared to diffusion process only.In 3-D environments, obtaining analytical solution for hitting timedistribution for realistic cases is complicated, hence we develop an end-to-endsimulator for he diffusion-based communication system that sends consecutivesymbols.  In CvD, each symbol is modulated and demodulated in a time slot called symbolduration, however the long tail distribution of hitting time is the mainchallenge that affects the symbol detection error. The molecules arriving inthe following slots become an interference source when detection takes place.End-to-end simulator enables us to analyze the effect of inter symbolinterference (ISI) without making any assumptions on the ISI. We propose an ISIcancellation technique that utilizes decision feedback for compensating theeffect of previously demodulated symbol. Three different modulation types areconsidered with pulse, square, and cosine carrier waves. In case of constraintson transmitter or receiver node it may not be possible to use pulse as acarrier, and peak-to-average messenger molecule metric is defined for thispurpose. Results show that, the proposed ISI mitigation technique improves thesymbol detection performance and the amplitude-based modulations are improvedmore than frequency-based modulations.

Effect of ISI Mitigation on Modulation Techniques in Communication via Diffusion