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Searches for dark matter annihilation signals in the diffuse gamma-raybackground are promising. We present the first comprehensive study utilizingboth flux and anisotropy, using the example of a spectral line signal. Besidesimproving sensitivity, a combined analysis will help separately determine theparticle properties of dark matter and the cosmological aspects of its clumpinginto halo substructure. The significance of a signal in a shot-noise-dominatedanisotropy analysis increases linearly with time $t$, as opposed to $\sqrt{t}$for a flux analysis, so a flux hint might be confirmed with an anisotropysignal. A first combined line search with Fermi-LAT would provide powerful newsensitivity; one with the proposed GAMMA-400 would be dramatically better.

Combined Flux and Anisotropy Searches Improve Sensitivity to Gamma Rays from Dark Matter