English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Optical mapping by direct visualization of individual DNA molecules,stretched in nanochannels with sequence-specific fluorescent labeling,represents a promising tool for disease diagnostics and genomics. An importantchallenge for this technique is thermal motion of the DNA as it undergoesimaging; this blurs fluorescent patterns along the DNA and results ininformation loss. Correcting for this effect (a process referred to askymograph alignment) is a common preprocessing step in nanochannel-basedoptical mapping workflows, and we present here a highly efficient algorithm toaccomplish this via pattern recognition. We compare our method with the oneprevious approach, and we find that our method is orders of magnitude fasterwhile producing data of similar quality. We demonstrate proof of principle ofour approach on experimental data consisting of melt mapped bacteriophage DNA.

A fast and scalable kymograph alignment algorithm for nanochannel-based optical DNA mappings