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A technology for recording electrical activity of large neuron populations atarbitrary depth in brain tissues with less than cell spatial and millisecondtemporal resolutions was the most craving dream of neuroscientists and a longpursued goal of engineers for decades. Even though many imaging techniques havebeen devised up to date, none of them is capable to deliver eitherquantitatively valid data nor able to meet contradictory requirements posed forsensors to be safe, non-invasive and reliably working either within culturedcell populations or during chronic implantations in vivo. In my researchproject, I design and justify a novel nanobiosensors, capable to detect andoptically report the electric fields across cellular membrane and investigateproperties of that specially engineered plasmonic nanoantennas. In thefollowing literature survey, I observe the current state of electrophysiologymethods and after recalling the basics of fluorescence, discuss benefits anddrawbacks of today's voltage sensitive labelling and electric fields imagingmethods. This review is wrapped up by a brief outlook of prospectiveapplications of this technology.

Imaging electrical activity of neurons with metamaterial nanosensors