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The behaviour of an organism often reflects a strategy for coping with itsenvironment. Such behaviour in higher organisms can often be reduced to a fewstereotyped modes of movement due to physiological limitations, but findingsuch modes in amoeboid cells is more difficult as they lack these constraints.Here, we examine cell shape and movement in starved Dictyostelium amoebaeduring migration toward a chemoattractant in a microfluidic chamber. We showthat the incredible variety in amoeboid shape across a population can bereduced to a few modes of variation. Interestingly, cells use distinct modesdepending on the applied chemical gradient, with specific cell shapesassociated with shallow, difficult-to-sense gradients. Modelling and drugtreatment reveals that these behaviours are intrinsically linked with accuratesensing at the physical limit. Since similar behaviours are observed in adiverse range of cell types, we propose that cell shape and behaviour areconserved traits.

Distinct cell shapes determine accurate chemotaxis