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Efron et al. (2001) proposed empirical Bayes formulation of the frequentistBenjamini and Hochbergs False Discovery Rate method (Benjamini andHochberg,1995). This article attempts to unify the `two cultures' usingconcepts of comparison density and distribution function. We have also shownhow almost all of the existing local fdr methods can be viewed as proposingvarious model specification for comparison density - unifies the vastliterature of false discovery methods under one concept and notation.

CDfdr: A Comparison Density Approach to Local False Discovery Rate Estimation