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Tungsten microneedles are currently used to insert neural electrodes intoliving peripheral nerves. However, the biomechanics underlying these proceduresis not yet well characterized. For this reason, the aim of this work was tomodel the interactions between these microneedles and living peripheral nerves.A simple mathematical framework was especially provided to model bothcompression of the external layer of the nerve (epineurium) and theinteractions resulting from penetration of the main shaft of the microneedleinside the living nerves. The instantaneous Young's modulus, compression force,the work needed to pierce the tissue, puncturing pressure, and the dynamicfriction coefficient between the tungsten microneedles and living nerves werequantified starting from acute experiments, aiming to reproduce the physicalenvironment of real implantations. Indeed, a better knowledge of theinteractions between microneedles and peripheral nerves may be useful toimprove the effectiveness of these insertion techniques, and could represent akey factor for designing robot-assisted procedures tailored for peripheralnerve insertion.

In vivo interactions between tungsten microneedles and peripheral nerves