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In previous works, the author and collaborators establish a mathematicalmodel for injury response in articular cartilage. In this paper we usemathematical software and computational techniques, applied to an existingmodel to explore in more detail how the behavior of cartilage cells isinfluenced by several of, what are believed to be, the most significantmechanisms underlying cartilage injury response at the cellular level. Weintroduce a control parameter, the radius of attenuation, and present some newsimulations that shed light on how inflammation associated with cartilageinjuries impacts the metabolic activity of cartilage cells. The detailspresented in the work can help to elucidate targets for more effectivetherapies in the preventative treatment of post-traumatic osteoarthritis.

A Measure of Control for Secondary Cytokine-Induced Injury of Articular Cartilage: A Computational Study