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In large populations, multiple beneficial mutations may be simultaneouslyspreading. In asexual populations, these mutations must either arise on thesame background or compete against each other. In sexual populations,recombination can bring together beneficial alleles from different backgrounds,but tightly linked alleles may still greatly interfere with each other. We showfor well-mixed populations that when this interference is strong, the genomecan be seen as consisting of many effectively asexual stretches linkedtogether. The rate at which beneficial alleles fix is thus roughly proportionalto the rate of recombination, and depends only logarithmically on the mutationsupply and the strength of selection. Our scaling arguments also allow topredict, with reasonable accuracy, the distribution of effects of fixedmutations when new mutations have broadly-distributed effects. We focus on theregime in which crossovers occur more frequently than beneficial mutations, asis likely to be the case for many natural populations.

The rate of adaptation in large sexual populations with linear chromosomes