English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

We show that a normalized alignment free similarity measure, called D2z, canbe used to detect potential regulatory relations for gene sets when little isknown about the regulatory elements involved. One scenario where such gene setsarise is genome wide association studies (GWAS). In this work we consider agene set from a GWAS on childhood general cognitive ability. We build aco-regulation network for the GWAS genes based on the D2z scores, which showspotential co-regulatory relationships between the genes as well as predictadditional genes that are likely to be part of the network. We found that theset of the predicted genes is enriched in genes associated with mentalretardation and GO terms such as synapse and neuron development. In particular,we found strong evidence of regulatory connection between the GWAS genes andCHL1, a gene known to be involved in mental retardation.

Genome wide identification of regulatory networks associated with  general cognitive ability using a normalized alignment free similarity  measure of promoter regions